CALL FOR PAPERS Small Vessels–Big Problems: Novel Insights into Microvascular Mechanisms of Diseases Effect of PDE5 inhibition on the modulation of sympathetic -adrenergic vasoconstriction in contracting skeletal muscle of young and older recreationally active humans
نویسندگان
چکیده
Michael Nyberg, Peter Piil, Jon Egelund, Randy S. Sprague, Stefan P. Mortensen, and Ylva Hellsten Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Department of Pharmacological and Physiological Science, St. Louis University School of Medicine, St. Louis, Missouri; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; and The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
منابع مشابه
Effect of PDE5 inhibition on the modulation of sympathetic α-adrenergic vasoconstriction in contracting skeletal muscle of young and older recreationally active humans.
Aging is associated with an altered regulation of blood flow to contracting skeletal muscle; however, the precise mechanisms remain unclear. We recently demonstrated that inhibition of cGMP-binding phosphodiesterase 5 (PDE5) increased blood flow to contracting skeletal muscle of older but not young human subjects. Here we examined whether this effect of PDE5 inhibition was related to an improve...
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The neuronal isoform of nitric oxide synthase (nNOS) is highly expressed in mammalian skeletal muscle, but its functional role has not been defined. NO has been implicated in the local metabolic regulation of blood flow in contracting skeletal muscle in part by antagonizing sympathetic vasoconstriction. We therefore hypothesized that nNOS in skeletal muscle is the source of the NO mediating the...
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Aging is associated with progressive loss of cardiovascular and skeletal muscle function. The impairment in physical capacity with advancing age could be related to an insufficient peripheral O2 delivery to the exercising muscles. Furthermore, the mechanisms underlying an impaired blood flow regulation remain unresolved. Cyclic guanosine monophosphate (cGMP) is one of the main second messengers...
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Reho JJ, Fisher SA. The stress of maternal separation causes misprogramming in the postnatal maturation of rat resistance arteries. Am J Physiol Heart Circ Physiol 309: H1468–H1478, 2015. First published September 14, 2015; doi:10.1152/ajpheart.00567.2015.—We examined the effect of stress in the first 2 wk of life induced by brief periods of daily maternal separation on developmental programmin...
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